Transcriptional control of the cellulase genes in Trichoderma reesei
The expression of the cellulase transcripts of Trichoderma reesei is controlled by the nature of the energy carbon sources used in the culture medium. Cellulose and the soluble disacharide sophorose, but not glycerol or glucose, act as inducers. Evidence is presented suggesting that a low constitutive extracellular cellulolytic system catalyzes the formation of a soluble inducer from cellulose, and this inducer triggers the expression of the cellulose transcripts. This basal and cellulose-induced expression of the cellobiohydrolase I mRNAs (cbh1) the major member of the cellulase system, is transcriptionally controlled by two independent cis-acting DNA regions. In addition, expression of the cbh1 transcript is influenced by the physiological state of the mitochondria and this sensitivity is controlled through the 5-flanking DNA sequence of this gene.

Apoio financeiro: PDADCT/CNPq e FAPESP.


Laboratório de Genômica e Expressão

+55 19 3521-6237 Contato por e-mail
Cidade Universitária Zeferino Vaz, 13083-970, Campinas, SP Como chegar?




Utilize o formulário ao lado para entrar em contato conosco.

 

Também estamos disponíveis através do telefone

+55 19 3521-6237

Ou diretamente pelo e-mail

suporte@lge.ibi.unicamp.br

A localização do LGE pode ser conferida no mapa abaixo. Demais formas de acesso à Unicamp podem ser consultadas clicando aqui.